Fri Aug 02 2024

118 articles - From Friday Jul 26 2024 to Friday Aug 02 2024

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Guidelines

Guidelines and related publications, position statements, white papers, technical reviews, consensus statements, etc…

Gastrointest Endosc

American Society for Gastrointestinal Endoscopy guideline on the role of therapeutic EUS in the management of biliary tract disorders: summary and recommendations.

4: The role of EUS-BD versus E-ERCP and PTBD in resolving biliary obstruction in patients with surgically altered anatomy other than RYGB. 5: In patients with acute cholecystitis who are not candidates for cholecystectomy, how does EUS-guided gallbladder drainage (EUS-GBD) compare with percutaneous gallbladder drainage and endoscopic transpapillary transcystic gallbladder drainage in resolving acute cholecystitis?

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Meta-analysis

meta-analyses and systematic reviews

Aliment Pharmacol Ther

Systematic review: Methotrexate-A poorly understood and underused medication in inflammatory bowel disease.

Methotrexate is effective at inducing and maintaining remission in steroid-refractory Crohn's disease and can reduce anti-TNF-induced immunogenicity when used in combination therapy. Data regarding tolerance and safety are reassuring. These findings challenge preconceived ideas on methotrexate and suggest that it is a valid first-line conventional option for the treatment of mild-to-moderate Crohn's disease.

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Am J Gastroenterol

Using Diet to Treat Inflammatory Bowel Disease: A Systematic Review.

Currently, there is limited evidence to support the use of specific diets to treat adult patients with mildly to moderately active IBD. Larger, randomized studies with standardized methodologies and outcome measures, rigorous adherence assessment, and an emphasis on endoscopic assessment outcome measures are required to validate most diets that have been studied for IBD. The included sample diet plans and dietary recommendations may prove helpful in the interim as part of a holistic strategy to manage patients with IBD.

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Clin Gastroenterol Hepatol

RISK OF DE NOVO BARRETT'S ESOPHAGUS POST SLEEVE GASTRECTOMY: A SYSTEMATIC REVIEW AND META-ANALYSIS OF STUDIES WITH LONG TERM FOLLOW UP.

Our analysis shows that SG results in a significantly increased risk of de novo BE and higher rates of EE, PPI use and HH. Our findings suggest that clinicians should routinely screen patients with SG for BE and future surveillance intervals should be followed as per societal guidelines.

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Original articles

RCT, clinical trials, retrospective studies, etc…

Aliment Pharmacol Ther

Efficacy and safety of risankizumab by baseline corticosteroid use and achievement of corticosteroid-free clinical and endoscopic outcomes in patients with moderately to severely active Crohn's disease.

Efficacy of risankizumab 600 mg induction therapy was independent of concomitant corticosteroid use. Risankizumab 180 and 360 mg maintenance therapy yielded high rates of corticosteroid-free clinical and endoscopic outcomes at week 52.

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Long-term safety and efficacy of filgotinib for the treatment of moderately to severely active ulcerative colitis: Interim analysis from up to 4 years of follow-up in the SELECTION open-label long-term extension study.

Safety results showed a proven long-term benefit-risk profile. FIL200-treated CDC achievers had better long-term outcomes than non-achievers.

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Prevalence and prognostic value of zinc and selenium deficiency in advanced chronic liver disease.

Zinc and selenium deficiencies are common in ACLD patients especially with higher MELD and HVPG. Low zinc and selenium levels independently predicted hepatic decompensation and liver-related death. The effect of zinc/selenium supplementation in ACLD should be investigated in future trials.

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The effect of dietary emulsifiers and thickeners on intestinal barrier function and its response to acute stress in healthy adult humans: A randomised controlled feeding study.

High intake of emulsifiers improved barrier function in the unstressed state, but increased intestinal permeability to stress, without evidence of inflammation. A LED was protective of the stress effect.

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Am J Gastroenterol

Antigliadin antibodies and the brain in people without celiac disease: a case-control study.

Our analysis is the most comprehensive to date and utilises a number of outcome measures known to be sensitive to subtle shifts in neurophysiology and cognition. Incidental AGA does not appear to be associated with any indications of neuropsychological deficit.

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Deep learning model using stool pictures for predicting endoscopic mucosal inflammation in patients with ulcerative colitis.

DLSUC demonstrated a good discriminating power similar to that of Fcal in predicting endoscopic activity with improved accuracy in patients without rectal sparing. This study implies that stool photos are a useful monitoring tool for typical UC.

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Delivery of Outpatient Cirrhosis Care Via Tele-visit is Not Associated with Increased Mortality as Compared to Traditional In-Person Visits.

Our findings suggest that outpatient cirrhosis care by tele-visit is associated with outcomes no worse than traditional in-person visits. This should reassure providers who hesitate to provide virtual care to patients with cirrhosis due to concerns for poorer outcomes.

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Inpatient Gastroenterology Consults Have Little Utility Prior to Transesophageal Echocardiograms in a Prospective Cohort Study.

Inpatient GI team workups to clear patients for a TEE found no contraindications to TEEs, did not change patient care plans, and led to increased hospital costs and lengths of stay.

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Linear-array Endoscopic Ultrasound and Narrow-Banding Imaging Measure the Invasion Depth of Nonpedunculated Rectal Lesions with Comparable Accuracy based on a Randomized Controlled Trial.

Linear EUS and NBI measure the invasion depth of NPRLs with comparable accuracy. The combination of the two methods does not improve the diagnostic accuracy. Single NBI should be preferred, considering its simplicity and convenience in clinical practice.

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Prevalence of Preceding and Follow-up Outpatient Care Surrounding Emergency Department Visits for Pediatric Inflammatory Bowel Disease: Identifying Opportunities for Quality Improvement.

Gaps in preceding and follow-up care signal opportunities to improve care quality.

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Risk of Small Intestine Cancer in Inflammatory Bowel Disease: A Propensity-Matched Study from a Large Multi-Center Database in the United States.

Both patients with CD and, interestingly, UC had an elevated risk for developing SBC compared to the general population.

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Severe Cholestasis Predicts Recurrent Primary Sclerosing Cholangitis Following Liver Transplantation.

The development of cholestasis within 3 to 12 months following LT was predictive of rPSC and graft loss.

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The Association Between Angiotensin Converting Enzyme Inhibitor or Angiotensin Receptor Blocker Exposure and Key Cirrhosis-Related Outcomes.

ACE-I/ARB exposure was associated with reduced mortality, potentially through CV and other (renal, malignancy-related) mechanisms. In patients with compensated disease, ACE-I/ARB was not associated with hepatic decompensation or HCC. Future research should identify subsets of patients who benefit from ACE-I/ARB exposure.

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Clin Gastroenterol Hepatol

Automated Neutrophil Quantification and Histological Score Estimation in Ulcerative Colitis.

The AI system's precise localization and quantification of neutrophils proved valuable for histological assessment and clinical prognosis stratification.

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Clinical Presentation and Outcomes of Alpha-Gal Syndrome.

A diagnosis of AGS should be strongly considered in patients with a history of tick bites and clinical presentation of allergic or GI manifestations. Dietary intervention is effective in most but not al patients.

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Defining and Understanding Diagnostic Delays Among Pancreatic Cancer Patients: A Retrospective Cohort Study.

Over one-third of pancreatic cancer patients experienced a diagnostic delay, mostly due to inadequate recognition of red-flag findings. Results can inform targeted interventions to reduce preventable diagnostic delays among pancreatic cancer patients.

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Endosc Int Open

Learning curve for endoscopic submucosal dissection (ESD) in the United States: Large, untutored, single-operator experience.

Following ex-vivo training in an animal model, an untutored expert operator achieved competency in ESD between 250 and 350 procedures. Our data can inform development of future training programs in the West.

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Mortality from upper gastrointestinal tumors in colorectal cancer screening patients.

10 mm and HGD. Future studies will demonstrate whether integrated screening with additional gastroscopy is effective in CRC screening participants with large or highly dysplastic polyps.

Pubmed   Journal   ReadQx   PMC

Value of green sign and chicken skin aspects for detecting malignancy of colorectal neoplasia in a prospective characterization study.

The green sign may be associated with malignant colorectal neoplasia. Targeting these areas before precise analysis of the lesion could be a way of improving detection of focal malignancies and prediction of the most severe histology.

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Endoscopy

Effect of Transcutaneous Electrical Nerve Stimulation Based on Wrist-Ankle Acupuncture Theory for Pain Relief during Non-Anesthetic Colonoscopy: A Randomized Controlled Trial.

TENS-WAA effectively reduces pain during non-anesthetized colonoscopy, especially in male participants, providing a promising non-invasive analgesic method.

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Gastroenterology

Long-term cost-effectiveness of case-finding and mass-screening for coeliac disease in children.

An earlier identification of CD through screening or case-finding in children using a POCT leads to improved health outcomes and is cost-effective in the long-term compared to current care. If the feasibility and acceptability of the proposed strategies are successful, implementation in Dutch regular care is needed.

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Mucosal Single-Cell Profiling of Crohn's-Like Disease of the Pouch Reveals Unique Pathogenesis and Therapeutic Targets.

Additionally, CDP pouch/ileum exhibited heightened endoplasmic reticulum (ER) stress across al major cell compartments. CDP likely represents a distinct entity of inflammatory bowel disease with heightened ER stress in both immune and non-immune cells, which may become a novel diagnostic biomarker and therapeutic target for CDP.

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Gastrointest Endosc

A prospective randomized controlled trial of water exchange plus cap versus water exchange colonoscopy in unsedated Veterans.

Unsedated colonoscopy was appropriate for unescorted Veterans. WE alone was sufficient. Adding a cap did not reduce RTMIP. Patient specific factors and application of WE with insertion suction of infused water contributed to high and low RTMIP, respectively. For unesorted patients, selecting those with low anxiety, avoiding low body mass index, history of depression or self-reported poor health and adhering to the steps of WE can minimize RTMIP to ensure success of unsedated colonoscopy.

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Adenoma detection rate and tolerability of two ultra-low volume bowel preparations in screening: a noninferiority randomized controlled trial.

Despite the superior bowel preparation quality associated with 1L-PEGA, the safety, tolerability and overall satisfaction of participants were higher with SPMC. (EudraCT: 2019-003186-18) on March 18, 2019.

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BOOSTING EFFICIENCY IN THE ENDOSCOPY SUITE: INTEGRATING TEAM WORKFLOWS IMPROVES PRODUCTIVITY AND MINIMIZES COST.

This study defines variations in TOT and demonstrates that finding imbalances and sharing the workload significantly cuts costs and improves the overall efficiency of the different subgroups in the turnover process.

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Distal Cap-assisted Endoscopic Mucosal Resection allows the safe and effective resection of adherent, dysplastic lesions in the setting of inflammatory bowel disease: a multicenter, retrospective study with video.

EMR-DC represents an attractive option for the resection of adherent dysplastic lesions in chronic IBD which is effective, safe, and inexpensive.

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Long-term outcomes of endoscopic ultrasonography-guided balloon-occluded gastrojejunostomy bypass for malignant gastric outlet obstruction (with video).

EPASS demonstrates safety and reliability in EUS-GE, offering a viable option for symptomatic malignant GOO treatment.

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THE ROLE OF MAGNETIC RESONANCE CHOLANGIOPANCREATOGRAPHY FOR PREVENTING PANCREATIC FLUID COLLECTION RECURRENCE AFTER EUS-GUIDED DRAINAGE OF WALLED-OFF NECROSIS.

Patients with WON who underwent MRCP prior to transmural stent removal had a lower rate of PFC recurrence largely due to the identification of DPD with appropriate endoscopic management.

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Gut

Association of breast milk-derived arachidonic acid-induced infant gut dysbiosis with the onset of atopic dermatitis.

Moreover, AA significantly increased IL-4 secretion in HaCaT cells costimulated with TNF-α and INF-γ. This study demonstrates that AA is intimately linked to the onset of AD via gut dysbiosis.

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Circulating tumour DNA in patients with hepatocellular carcinoma across tumour stages and treatments.

ctDNA offers dynamic information reflecting tumour biology. It represents a non-invasive tool useful to guide HCC clinical management.

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Combination of carvedilol with variceal band ligation in prevention of first variceal bleed in Child-Turcotte-Pugh B and C cirrhosis with high-risk oesophageal varices: the 'CAVARLY TRIAL'.

In CTP B and C cirrhosis patients with high-risk varices, combination of carvedilol and VBL is more effective than either therapy alone, for primary prevention of variceal bleeding.

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Impact of prenatal and postnatal maternal IBD status on offspring's risk of IBD: a population-based cohort study.

Offspring had a greater risk of IBD when either parent was diagnosed before childbirth rather than later, emphasising genetic predisposition and environmental risk factors rather than maternal inflammation in utero as risk factors for IBD.

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Hepatology

Exome-wide association analysis identifies novel risk loci for alcohol-associated hepatitis.

This study has identified two new genes of high effect size with a previously unknown contribution to ALD, and highlights both the overlap in etiology between liver diseases, and the unique origins of AH.

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Long-term outcome and risk stratification in compensated advanced chronic liver disease after HCV-cure.

Baveno VII criteria to exclude (FU-liver stiffness measurement 3 y). One-time post-treatment risk stratification based on noninvasive criteria provides important prognostic information that is maintained during long-term follow-up, as the hazards remain proportional over time.

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J Hepatol

Functional cure of hepatitis B in patients with cancer undergoing immune checkpoint inhibitor therapy.

ICIs may accelerate HBsAg seroclearance in cancer patients with baseline HBsAg <100 IU/ml. This finding provides important information for the design of future ICI trials to achieve functional cure in patients with CHB.

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Reviews&Editorials

Plenty of the editorials are available as full text through the publisher website using the provided link

Aliment Pharmacol Ther

Review article: Oesophageal disorders in chronic liver disease.

These conditions require careful management due to complex symptoms and treatment risks. Proton pump inhibitors and other therapies must be used cautiously, as cirrhosis interventions can worsen symptoms.

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Review article: advances in the diagnosis and management of anorectal motility disorders.

Anorectal motility disorders are common, but either less well recognized or poorly managed by most gastroenterologists. Equipped with the practical and up-to-date knowledge provided in this review, physicians could provide improved health care for these patients.

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Clin Gastroenterol Hepatol

Blue Notes.

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The Discrepant Visual Representation of Inflammatory Bowel Diseases in the Internet and Media.

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Endoscopy

ESGE and Education in Endoscopy.

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Endoscopy E-Videos - recently published.

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Gastroenterology

A further step toward possible treatment of alpha-1 antitrypsin deficiency associated liver disease.

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Miscellaneous

misc publications eg case reports, tools of the trade, images of the month, etc…

Am J Gastroenterol

A Rare Case of an Esophageal Leiomyoma With Ossification.

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Adult Chronic Intestinal Volvulus.

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Ascending Cholangitis in a Patient With Remote Cholecystectomy.

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Cap polyposis: a rare cause of rectal bleeding.

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Development of Giant Hepatocellular Carcinoma Leads to Biliary Plastic Stent Compression Resulting in Pseudoaneurysm Rupture in Right Hepatic Artery.

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Endoscopic Retrograde Cholangiopancreatography in COVID-Associated Cholangiopathy.

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Esophageal implantation metastasis of gastric cancer during specimen retrieval after endoscopic submucosal dissection.

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Fair Is Not Square: More Evidence Linking Bowel Cleanliness to Colonoscopy Outcomes.

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Further Questions Raised as to the Use of Anorectal Manometry in the Diagnostic Assessment of Dyssynergic Defecation.

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Gastric Mucosal Melanoma Mimicking Verrucous Gastritis.

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Management of Obscure Gastrointestinal Bleeding.

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Post-transplant Lymphoproliferative Disorder of the Epiglottis in a 21-Month-Old Child.

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Response to Lee.

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Response to Li et al.

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Unusual Endoscopic Findings of Mucosa-Associated Lymphoid Tissue Lymphoma.

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Update on Newly Federal Drug Administration-Approved Drug, Resmetirom: A Practical Perspective.

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Clin Gastroenterol Hepatol

Association Between Deep Sedation and Risk of Post-Colonoscopy Colorectal Cancer: Swedish Register Data 2007-2016.

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Diffuse Large B-Cell Duodenal Lymphoma Presenting with Obstruction and Pneumatosis.

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Esophageal large-cell neuroendocrine carcinoma mimicking benign submucosal tumor treated with endoscopic submucosal dissection.

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Performance of a Multi-Cancer Early Detection Test for Detection of Hepatocellular Carcinoma in Patients with Cirrhosis.

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Endosc Int Open

Strategies to successfully complete complex ESD in the colon.

Pubmed   Journal   ReadQx   PMC

Endoscopy

A novel strategy for performing endoscopic submucosal dissection for circumferential superficial esophageal neoplastic lesions with kissing traction.

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A radiation-free novel approach for intestinal stent placement: the "scope-in-scope" technique.

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Appendiceal fecalith misdiagnosed as cecal stromal tumor: don't fall into the trap.

Pubmed   Journal   ReadQx   PMC

Application of hemostatic forceps to treat post-sphincterotomy bleeding near the pancreatic duct opening.

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Cholangioscope-assisted endoscopic retrograde appendicitis therapy for occult chronic appendicitis.

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Cholangioscopy-guided laser ablation for intraductal papillary neoplasm of bile duct.

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Clinical application of a novel high-selectivity steerable-tip catheter for endoscopic retrograde cholangiopancreatography in patients with altered surgical anatomy.

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Deep invasive mucinous adenocarcinoma without surface amorphous pattern on inflammatory bowel disease: specific disease with specific characterization.

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Delayed-onset biliary peritonitis after endoscopic ultrasound-guided hepaticogastrostomy for malignant distal biliary obstruction.

Pubmed   Journal   ReadQx   PMC

Direct electrohydraulic lithotripsy with a novel peroral cholangioscope through the overtube for surgically-altered anatomy.

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Endoscopic ischemic polypectomy using a large endoclip for Peutz-Jeghers polyps.

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Endoscopic removal of magnetic beads causing duodenal chronic fistula.

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Endoscopic resection with an over-the-scope clip for recurrence of gastric cancer on the esophagus adjacent to the anastomosis after total gastrectomy.

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Endoscopic submucosal dissection of early gastric cancer using a novel image-enhanced endoscopy: amber-red color imaging.

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Endoscopic ultrasound-guided detection and internal drainage of a pancreato-cutaneous fistula after acute pancreatitis.

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Gel immersion technique in interventional endoscopic ultrasound for pancreatobiliary lesions.

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Integrated cholangioscopy-assisted lithotripsy and a novel basket approach for managing complex cystic duct confluence stones.

Pubmed   Journal   ReadQx   PMC

Mechanical failure of a curved linear array echoendoscope: loose fixation of the high frequency transducer.

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New drug-delivery balloon catheter for easy and fast injection of triamcinolone after esophageal endoscopic submucosal dissection.

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One-step technique for endoscopic ultrasound-guided hepaticogastrostomy using a partially covered metal stent for superficial bile duct access.

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Successful gastroduodenal stenting using the endoscopic ultrasound-guided rendezvous technique by Treitz ligament puncture.

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Technical tips for antegrade endopancreatic radiofrequency ablation for severe pancreatojejunal stricture.

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The characteristic "alveolus nest sign" in solid pseudopapillary neoplasm of the pancreas.

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Transcolonic endoscopic appendectomy via snare-through-line resection for stump appendicitis.

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Two-stage cap-assisted endoscopic mucosal resection and papillectomy for duodenal papillary tumors with lateral growth.

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Unexpected extraluminal omental bleeding during endoscopic full-thickness resection for a gastric subepithelial lesion.

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Gastroenterology

Acquisition of epithelial plasticity, and the potential origins of biphenotypic cells in chronic liver injury.

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GASTRO CURBSIDE CONSULT - AN UNEXPECTED CAUSE OF DYSPHAGIA.

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Head and Neck Pain in a Patient with Ulcerative Colitis.

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Gastrointest Endosc

Novel Rubber Band Assisting Closure Technique as A New Approach for The Closure of Large Mucosa Defect after Colorectal Endoscopic Submucosal Dissection.

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Hepatology

IBAT inhibitors in pediatric cholestatic liver diseases: Transformation on the horizon?

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J Hepatol

Intrahepatic immunity to hepatitis B virus.

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Letters&Replies

Letters to the editors and authors’ replies

Aliment Pharmacol Ther

'Letter: Role of Helicobacter pylori and metabolic syndrome-related insulin resistance and lipotoxicity in the pathogenesis of MAFLD and MASH-Authors' reply.

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Letter: Association between serum growth differentiation factor 15 and liver-related outcomes in patients with MASLD-Authors' reply.

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Letter: Association of serum growth differentiation factor 15 and liver-related outcomes in patients with MASLD.

Pubmed   Journal   ReadQx 

Letter: Critical appraisal of biologic therapy in early ulcerative colitis management-Addressing study limitations and the role of psychological resilience-Authors' reply.

Pubmed   Journal   ReadQx 

Letter: Critical appraisal of biologic therapy in management of early ulcerative colitis-Addressing study limitations and the role of psychological resilience.

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Letter: Role of Helicobacter pylori and metabolic syndrome-related insulin resistance and lipotoxicity in the pathogenesis of MAFLD and MASH.

Pubmed   Journal   ReadQx 

Clin Gastroenterol Hepatol

Comments on "Enduring Clinical Remission in Refractory Celiac Disease Type II with Tofacitinib: An Open-Label Clinical Study"".

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Non-invasive fibrosis tests require further evaluation in at risk populations.

Pubmed   Journal   ReadQx 

Response to Yi Bao, Y Xu.

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Endoscopy

Response to Larsen et al.

Pubmed   Journal   ReadQx 

The results reported by Van de Schootbrugge-Vandermeer et al. might not support their conclusions.

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Gut

Unravelling the obesity paradox in MASLD patients with extrahepatic cancer.

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J Hepatol

Fatigue is a symptom of clinical importance in patients with Primary Sclerosing Cholangitis (SOMA.LIV).

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High prevalence of steatotic liver disease and fibrosis in the general population: A large prospective study in China.

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Is liver fibrosis more advanced in MetALD than in MASLD?

Pubmed   Journal   ReadQx 

Pre-Transplant Immune Checkpoint Inhibitor Use: the Intersection Between Medicine, Surgery and Pharmacy.

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Shortening the albumin challenge from 48 to 24 hours may lead to overdiagnosis of hepatorenal syndrome-acute kidney injury and overtreatment with terlipressin.

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Strategic Timing and Patient Selection for ICIs Prior to Liver Transplantation for HCC.

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Synergy between public health policy and clinicians plays a key role in reducing fracture risk in patients with viral hepatitis.

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