118 articles - From Friday Jul 26 2024 to Friday Aug 02 2024
Guidelines and related publications, position statements, white papers, technical reviews, consensus statements, etc…
| Gastrointest Endosc |
|---|
American Society for Gastrointestinal Endoscopy guideline on the role of therapeutic EUS in the management of biliary tract disorders: summary and recommendations. 4: The role of EUS-BD versus E-ERCP and PTBD in resolving biliary obstruction in patients with surgically altered anatomy other than RYGB. 5: In patients with acute cholecystitis who are not candidates for cholecystectomy, how does EUS-guided gallbladder drainage (EUS-GBD) compare with percutaneous gallbladder drainage and endoscopic transpapillary transcystic gallbladder drainage in resolving acute cholecystitis? |
meta-analyses and systematic reviews
| Aliment Pharmacol Ther |
|---|
Systematic review: Methotrexate-A poorly understood and underused medication in inflammatory bowel disease. Methotrexate is effective at inducing and maintaining remission in steroid-refractory Crohn's disease and can reduce anti-TNF-induced immunogenicity when used in combination therapy. Data regarding tolerance and safety are reassuring. These findings challenge preconceived ideas on methotrexate and suggest that it is a valid first-line conventional option for the treatment of mild-to-moderate Crohn's disease. |
| Am J Gastroenterol |
Using Diet to Treat Inflammatory Bowel Disease: A Systematic Review. Currently, there is limited evidence to support the use of specific diets to treat adult patients with mildly to moderately active IBD. Larger, randomized studies with standardized methodologies and outcome measures, rigorous adherence assessment, and an emphasis on endoscopic assessment outcome measures are required to validate most diets that have been studied for IBD. The included sample diet plans and dietary recommendations may prove helpful in the interim as part of a holistic strategy to manage patients with IBD. |
| Clin Gastroenterol Hepatol |
RISK OF DE NOVO BARRETT'S ESOPHAGUS POST SLEEVE GASTRECTOMY: A SYSTEMATIC REVIEW AND META-ANALYSIS OF STUDIES WITH LONG TERM FOLLOW UP. Our analysis shows that SG results in a significantly increased risk of de novo BE and higher rates of EE, PPI use and HH. Our findings suggest that clinicians should routinely screen patients with SG for BE and future surveillance intervals should be followed as per societal guidelines. |
RCT, clinical trials, retrospective studies, etc…
| Aliment Pharmacol Ther |
|---|
Efficacy and safety of risankizumab by baseline corticosteroid use and achievement of corticosteroid-free clinical and endoscopic outcomes in patients with moderately to severely active Crohn's disease. Efficacy of risankizumab 600 mg induction therapy was independent of concomitant corticosteroid use. Risankizumab 180 and 360 mg maintenance therapy yielded high rates of corticosteroid-free clinical and endoscopic outcomes at week 52. |
Long-term safety and efficacy of filgotinib for the treatment of moderately to severely active ulcerative colitis: Interim analysis from up to 4 years of follow-up in the SELECTION open-label long-term extension study. Safety results showed a proven long-term benefit-risk profile. FIL200-treated CDC achievers had better long-term outcomes than non-achievers. |
Prevalence and prognostic value of zinc and selenium deficiency in advanced chronic liver disease. Zinc and selenium deficiencies are common in ACLD patients especially with higher MELD and HVPG. Low zinc and selenium levels independently predicted hepatic decompensation and liver-related death. The effect of zinc/selenium supplementation in ACLD should be investigated in future trials. |
The effect of dietary emulsifiers and thickeners on intestinal barrier function and its response to acute stress in healthy adult humans: A randomised controlled feeding study. High intake of emulsifiers improved barrier function in the unstressed state, but increased intestinal permeability to stress, without evidence of inflammation. A LED was protective of the stress effect. |
| Am J Gastroenterol |
Antigliadin antibodies and the brain in people without celiac disease: a case-control study. Our analysis is the most comprehensive to date and utilises a number of outcome measures known to be sensitive to subtle shifts in neurophysiology and cognition. Incidental AGA does not appear to be associated with any indications of neuropsychological deficit. |
Deep learning model using stool pictures for predicting endoscopic mucosal inflammation in patients with ulcerative colitis. DLSUC demonstrated a good discriminating power similar to that of Fcal in predicting endoscopic activity with improved accuracy in patients without rectal sparing. This study implies that stool photos are a useful monitoring tool for typical UC. |
Delivery of Outpatient Cirrhosis Care Via Tele-visit is Not Associated with Increased Mortality as Compared to Traditional In-Person Visits. Our findings suggest that outpatient cirrhosis care by tele-visit is associated with outcomes no worse than traditional in-person visits. This should reassure providers who hesitate to provide virtual care to patients with cirrhosis due to concerns for poorer outcomes. |
Inpatient Gastroenterology Consults Have Little Utility Prior to Transesophageal Echocardiograms in a Prospective Cohort Study. Inpatient GI team workups to clear patients for a TEE found no contraindications to TEEs, did not change patient care plans, and led to increased hospital costs and lengths of stay. |
Linear-array Endoscopic Ultrasound and Narrow-Banding Imaging Measure the Invasion Depth of Nonpedunculated Rectal Lesions with Comparable Accuracy based on a Randomized Controlled Trial. Linear EUS and NBI measure the invasion depth of NPRLs with comparable accuracy. The combination of the two methods does not improve the diagnostic accuracy. Single NBI should be preferred, considering its simplicity and convenience in clinical practice. |
The Association Between Angiotensin Converting Enzyme Inhibitor or Angiotensin Receptor Blocker Exposure and Key Cirrhosis-Related Outcomes. ACE-I/ARB exposure was associated with reduced mortality, potentially through CV and other (renal, malignancy-related) mechanisms. In patients with compensated disease, ACE-I/ARB was not associated with hepatic decompensation or HCC. Future research should identify subsets of patients who benefit from ACE-I/ARB exposure. |
| Clin Gastroenterol Hepatol |
Defining and Understanding Diagnostic Delays Among Pancreatic Cancer Patients: A Retrospective Cohort Study. Over one-third of pancreatic cancer patients experienced a diagnostic delay, mostly due to inadequate recognition of red-flag findings. Results can inform targeted interventions to reduce preventable diagnostic delays among pancreatic cancer patients. |
| Endosc Int Open |
Learning curve for endoscopic submucosal dissection (ESD) in the United States: Large, untutored, single-operator experience. Following ex-vivo training in an animal model, an untutored expert operator achieved competency in ESD between 250 and 350 procedures. Our data can inform development of future training programs in the West. |
Value of green sign and chicken skin aspects for detecting malignancy of colorectal neoplasia in a prospective characterization study. The green sign may be associated with malignant colorectal neoplasia. Targeting these areas before precise analysis of the lesion could be a way of improving detection of focal malignancies and prediction of the most severe histology. |
| Endoscopy |
Effect of Transcutaneous Electrical Nerve Stimulation Based on Wrist-Ankle Acupuncture Theory for Pain Relief during Non-Anesthetic Colonoscopy: A Randomized Controlled Trial. TENS-WAA effectively reduces pain during non-anesthetized colonoscopy, especially in male participants, providing a promising non-invasive analgesic method. |
| Gastroenterology |
Long-term cost-effectiveness of case-finding and mass-screening for coeliac disease in children. An earlier identification of CD through screening or case-finding in children using a POCT leads to improved health outcomes and is cost-effective in the long-term compared to current care. If the feasibility and acceptability of the proposed strategies are successful, implementation in Dutch regular care is needed. |
Mucosal Single-Cell Profiling of Crohn's-Like Disease of the Pouch Reveals Unique Pathogenesis and Therapeutic Targets. Additionally, CDP pouch/ileum exhibited heightened endoplasmic reticulum (ER) stress across al major cell compartments. CDP likely represents a distinct entity of inflammatory bowel disease with heightened ER stress in both immune and non-immune cells, which may become a novel diagnostic biomarker and therapeutic target for CDP. |
| Gastrointest Endosc |
A prospective randomized controlled trial of water exchange plus cap versus water exchange colonoscopy in unsedated Veterans. Unsedated colonoscopy was appropriate for unescorted Veterans. WE alone was sufficient. Adding a cap did not reduce RTMIP. Patient specific factors and application of WE with insertion suction of infused water contributed to high and low RTMIP, respectively. For unesorted patients, selecting those with low anxiety, avoiding low body mass index, history of depression or self-reported poor health and adhering to the steps of WE can minimize RTMIP to ensure success of unsedated colonoscopy. |
Adenoma detection rate and tolerability of two ultra-low volume bowel preparations in screening: a noninferiority randomized controlled trial. Despite the superior bowel preparation quality associated with 1L-PEGA, the safety, tolerability and overall satisfaction of participants were higher with SPMC. (EudraCT: 2019-003186-18) on March 18, 2019. |
BOOSTING EFFICIENCY IN THE ENDOSCOPY SUITE: INTEGRATING TEAM WORKFLOWS IMPROVES PRODUCTIVITY AND MINIMIZES COST. This study defines variations in TOT and demonstrates that finding imbalances and sharing the workload significantly cuts costs and improves the overall efficiency of the different subgroups in the turnover process. |
Distal Cap-assisted Endoscopic Mucosal Resection allows the safe and effective resection of adherent, dysplastic lesions in the setting of inflammatory bowel disease: a multicenter, retrospective study with video. EMR-DC represents an attractive option for the resection of adherent dysplastic lesions in chronic IBD which is effective, safe, and inexpensive. |
THE ROLE OF MAGNETIC RESONANCE CHOLANGIOPANCREATOGRAPHY FOR PREVENTING PANCREATIC FLUID COLLECTION RECURRENCE AFTER EUS-GUIDED DRAINAGE OF WALLED-OFF NECROSIS. Patients with WON who underwent MRCP prior to transmural stent removal had a lower rate of PFC recurrence largely due to the identification of DPD with appropriate endoscopic management. |
| Gut |
Association of breast milk-derived arachidonic acid-induced infant gut dysbiosis with the onset of atopic dermatitis. Moreover, AA significantly increased IL-4 secretion in HaCaT cells costimulated with TNF-α and INF-γ. This study demonstrates that AA is intimately linked to the onset of AD via gut dysbiosis. |
Combination of carvedilol with variceal band ligation in prevention of first variceal bleed in Child-Turcotte-Pugh B and C cirrhosis with high-risk oesophageal varices: the 'CAVARLY TRIAL'. In CTP B and C cirrhosis patients with high-risk varices, combination of carvedilol and VBL is more effective than either therapy alone, for primary prevention of variceal bleeding. |
Impact of prenatal and postnatal maternal IBD status on offspring's risk of IBD: a population-based cohort study. Offspring had a greater risk of IBD when either parent was diagnosed before childbirth rather than later, emphasising genetic predisposition and environmental risk factors rather than maternal inflammation in utero as risk factors for IBD. |
| Hepatology |
Exome-wide association analysis identifies novel risk loci for alcohol-associated hepatitis. This study has identified two new genes of high effect size with a previously unknown contribution to ALD, and highlights both the overlap in etiology between liver diseases, and the unique origins of AH. |
Long-term outcome and risk stratification in compensated advanced chronic liver disease after HCV-cure. Baveno VII criteria to exclude (FU-liver stiffness measurement 3 y). One-time post-treatment risk stratification based on noninvasive criteria provides important prognostic information that is maintained during long-term follow-up, as the hazards remain proportional over time. |
| J Hepatol |
Functional cure of hepatitis B in patients with cancer undergoing immune checkpoint inhibitor therapy. ICIs may accelerate HBsAg seroclearance in cancer patients with baseline HBsAg <100 IU/ml. This finding provides important information for the design of future ICI trials to achieve functional cure in patients with CHB. |
Plenty of the editorials are available as full text through the publisher website using the provided link
| Aliment Pharmacol Ther |
|---|
Review article: advances in the diagnosis and management of anorectal motility disorders. Anorectal motility disorders are common, but either less well recognized or poorly managed by most gastroenterologists. Equipped with the practical and up-to-date knowledge provided in this review, physicians could provide improved health care for these patients. |
| Clin Gastroenterol Hepatol |
| Endoscopy |
| Gastroenterology |
misc publications eg case reports, tools of the trade, images of the month, etc…
| Am J Gastroenterol |
|---|
| Clin Gastroenterol Hepatol |
| Endosc Int Open |
| Endoscopy |
| Gastroenterology |
| Gastrointest Endosc |
| Hepatology |
| J Hepatol |
Letters to the editors and authors’ replies
| Aliment Pharmacol Ther |
|---|
| Clin Gastroenterol Hepatol |
| Endoscopy |
| Gut |
| J Hepatol |